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From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)

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The NO system is attractive as a research framework because it can connect several observations that otherwise appear separate

Free radicals may contribute to oxidative skeletal muscle fatigue
Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z et al
