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220 However, the total depletion of NAD + could be very toxic to noncancerous cells, thereby it has been considered to rescue them using NAPRT precursor, nicotinic acid
When used in combination with levodopa, certain phytochemicals(such as curcumin, resveratrol, and quercetin) have demonstrated synergistic effects, potentially enhancing motor function, reducing levodopainduced toxicity, and prolonging its therapeutic efficacy

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doi: 10.3389/fphar.2019.00229 209 ManchopeMFCalixto-CamposCCoelho-SilvaLZarpelonACPinho-RibeiroFAGeorgettiSRet al
