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doi: 10.1146/annurev-immunol-081022-021207 105 DeWulfBMinsartLVerdonkFKruysVPiagnerelliMMazeMet al

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Cell 186 , 305326.e327 (2023)

Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

As emphasized by Varma and colleagues, traditional single-layer kill-switch mechanisms often exhibit instability and may lose functionality within days, whereas multilayered systemsparticularly those combining CRISPR-inducible modules, toxinantitoxin systems, and synthetic auxotrophiesdemonstrate markedly greater robustness, maintaining containment across hundreds of generations (Varma et al., 2025)
