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They found that at the highest dosage of 4.8 mg survodutide weekly, study participants lost 14.9% of their body weight in comparison with a placebo group (2.8% weight loss) [122]

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However, the use of ERK1/2 or JNK inhibitors inhibited the growth of colon cancer cells in vivo and in vitro, suggesting that the activation of ERK1/2 and JNK signaling by insulin and IGF-1 is at least partially responsible for the development of T2DM-associated colon cancer (96)