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Unlike some other vitamins, cobalamin is not synthesized in the body

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To put that in perspective: if your therapeutic dose is 500 mcg, you'd theoretically need 500,000 mcg (500 mg) to approach potentially toxic levels

however, they were confirmed after inclusion in the study according to the Diagnostic Statistical Manual (DSM-IV and DSM-V) criteria assessed by clinical psychologists using the ADOS and Autism Diagnostic Interview-Revised (ADI-R) test at baseline

Extracts from water blanks were also injected as were toluene blanks every 10th injection