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When to seek urgent medical advice : Sudden worsening of joint pain, swelling, or stiffness Signs of infection (fever, malaise, localised warmth) Severe abdominal pain (potential pancreatitis if on GLP-1 therapy) Unexplained persistent nausea or vomiting Any concerning new symptoms after starting any new medication According to NICE Quality Standard 33, if you have suspected persistent synovitis, you should be referred to rheumatology within 3 working days and assessed within 3 weeks

Semaglutide and Tirzepatide work by stimulating GLP-1 receptors in the brain, which help control appetite, increase feelings of fullness, and regulate blood sugar levels

Why It Happens Diarrhea can occur with GLP-1 medications, particularly during the first few weeks of treatment or after dose increases

The cardiovascular risk profile of the average participant at week 24 looks meaningfully better than it did at week zero, independent of the weight loss itself

If youre dragging, a bigger breakfast or a snack can assist