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While this is not a comprehensive review of genetic predispositions for potential psychiatric side effects following GLP-1 signaling, it highlights the importance of future research to better understand individual factors that could contribute to conditions such as depression, anxiety, and suicidal ideation following GLP-1 use

Recently, rare but serious psychiatric adverse events (AEs) associated with GLP1-RA, such as suicide and self-injury, have gained attention [7]

Sedentary lifestyle, as well as the excessive consumption of calorie-dense foods, has established an obesogenic environment and contributed to a serious obesity epidemic

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