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JAMA Psychiatry Editor in Chief Dost ngr, MD, PhD, explains why his 2025 pick for Editors Choice: Clinical Trials of the Year is a randomized clinical trial showing that semaglutide is safe and effective in patients with schizophrenia who also experience overweight or #obesity and #prediabetes

Semaglutide peaks in your bloodstream 13 days after injection, with maximum appetite suppression typically occurring by day 45 of your weekly dose cycle

Glycerol can enter the liver for gluconeogenesis and changes in FFA levels affect systemic insulin sensitivity, thereby influencing glucose uptake by skeletal muscles and contributing to whole-body glucose homeostasis