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Phasic burst firing of midbrain dopamine neurons and subsequent phasic release of dopamine in the nucleus accumbens are key neurophysiological mechanisms that implicate mesolimbic dopamine signaling as critical for goal-directed behaviors including drug reinforcement [3641]

Back then, the once-weekly drug was only approved to treat type 2 diabetes

Fasting glucose typically begins dropping within 24 weeks, and some patients notice improvements in triglycerides

(November 25, 2025)