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SCFA are able to modulate cytokine and chemokine expression of immune cells and adipocytes (190)
GIP receptor stimulation enhances insulin sensitivity and promotes glucose uptake in peripheral tissues
Researchers became interested when preclinical studies demonstrated that adding glucagon receptor agonism to incretin-based therapy produced metabolic effects that exceeded those of GLP-1 or GIP activation aloneparticularly in energy expenditure and hepatic lipid metabolism
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