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Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

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In this regard, GLP-1 and exenatide dose-dependently protected SH-SY5Y cells from H 2 O 2 induced cell death

Katherine Cahill with Vanderbilt University Medical Center