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Description
GRP stimulation of GLP-1 secretion has also been demonstrated for rat L-cell cultures and in preparations of rat ileum [323,335]

Semaglutide interacted with circumventricular organs, where GLP-1R expression is abundant, and with regions protected by the BBB (lateral septal nucleus, nucleus tractus solitarius, hypothalamic arcuate nucleus) (102)

A one-way ANOVA with Tukeys posthoc test was used

Butsch also points out that there arent any official or standard guidelines for microdosing semaglutide or tirzepatide, and microdosing isnt endorsed by the American Diabetes Association

doi: 10.1038/nrclinonc.2016.206 97 QuoyerJLonguetCBrocaCLinckNCostesSVarinEet al
