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This also had an impact on sensitivity analysis 4, which adjusted for baseline HbA1c and body weight in patients on metformin in SURPASS2 and patients on metformin with or without a sulphonylurea in SUSTAIN FORTE

For protocol design, this triple mechanism has practical implications

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More importantly, tirzepatide influences the expression of microRNAs, such as miRNA-34a, miRNA-212, and miRNA-29c, which are involved in the regulation of neuronal growth, apoptosis, and differentiation, respectively [79, 84]