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Finally, although genetic manipulation is one of the strengths of preclinical work, it is important to recognize that transgenic manipulations can induce developmental compensations in parallel pathways that can mask the overall effect of loss of the gene on surgical outcome

GIP, another type of incretin, contributes to improving white adipose tissue function by increasing fat storage and reducing visceral ectopic deposition

As programs evolve beyond one-time treatments into longitudinal care models, having systems that support structured documentation, medication management, and outcome tracking becomes essential

5,6 Loss of muscle mass can also contribute to weight gain during menopause

But, as always in medicine, there is no free lunch