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The SURMOUNT-1 trial, also in the New England Journal of Medicine, studied tirzepatide in adults with obesity or overweight without type 2 diabetes

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The first study to demonstrate the effect of GLP-1RAs in reducing cardiovascular events was LEADER, in which 9340 patients with type 2 diabetes at high cardiovascular risk were randomized to liraglutide 1.8 mg per day or placebo [16]